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Preclinical Research Suggests Anti-cancer Effect Of Keto Diet

IMAGE: University of Texas at Dallas researchers studied the effects of a ketogenic diet on mice genetically engineered to develop lung cancer that closely mimics human cancer. It's well known that keeping blood glucose levels in check can help individuals avoid or manage diabetes, but new research led by biologists at The University of Texas at Dallas suggests that restricting blood glucose levels might also keep certain cancers at bay. In a study published online Aug. 13 in the journal Cell Reports, researchers restricted circulating glucose in mice with lung cancer. Circulating glucose restriction was achieved by feeding the mice a ketogenic diet, which is very low in sugar, and by giving them a diabetes drug that prevents glucose in the blood from being reabsorbed by the kidneys. Dr. Jung-Whan "Jay" Kim, corresponding author of the multinational study and an assistant professor of biological sciences at UT Dallas. While many types of cancer cells are suspected to be heavily dependent on glucose -- or sugar -- as their energy supply, Kim and his colleagues have shown in previous laboratory studies that one specific type -- squamous cell carcinoma -- is remarkably more dependent than other cancer types, such as adenocarcinoma. Kim noted that glucose restriction did not have any effect on non-squamous-cell cancer types. The researchers also examined glucose levels in blood samples from 192 patients who had either lung or esophageal squamous cell cancer, as well as 120 patients with lung adenocarcinoma. The blood samples were taken at random parts of the day and classified into those containing glucose concentrations higher or lower than 120 mg/dL, which is one clinical measure of diabetes. None of the patients had been diagnosed with diabetes. Kim emphasized that more comprehensive and detailed clinical studies are needed, but the results indicate a potentially novel approach to enhancing cancer treatment.


In a more conventional weight loss diet with an exercise plan, losing 2 lbs a week is the norm. On a keto diet, dieters can see up to 10-pound weight loss within the first week. Some dieters have even reported a loss of 7, 10, or even 12 pounds immediately after starting a keto diet. But again, weight loss results on any diet including the ketogenic diet can vary. And you may lose more or less depending on many personal factors. To shed light on what’s possible, here are some crazy keto results. These are weight-loss transformations that happened by following the keto diet. These positive keto reviews really highlight the effectiveness of the keto diet. And more likely than not, you can see weight loss results right from the start. Despite that, keto weight loss doesn’t come easy on some. So if you’ve been on a keto diet for a week or more and not seeing any drop in weight, it’s time to take a look at why. Why am I not losing weight on the keto diet?


Based on the effectiveness of the keto diet for weight loss, it is very unlikely you are not losing weight on keto. But of course, that’s if you are doing the keto diet correctly. Some keto dieters may find that they are not experiencing any drop in weight on keto. Too often, this can happen when you actually never hit ketosis despite following the diet. In general, here are possible reasons why you are not losing weight or reaching ketosis. Eating too many carbs. Eating too many carbs on keto is a common mistake on keto. And it’s a top reason for dieters not losing weight on keto. Without minimizing carbs to where it needs to be, it becomes that much harder to reach ketosis. To avoid this pitfall, keep your carbs low to the minimum. Carbs shouldn’t represent more than 10% of your calorie intake. Eating too many calories. Even on a keto, it’s essential to create a caloric deficit to enforce weight loss. You can achieve this by reducing your overall calorie intake or upping your exercise.


If you start a keto diet and don’t watch your calorie intake, you’re unlikely to drop pounds. It’s essential that you pay attention to your portion size. And choose keto snacks and meals that are filling without excessive calories. By avoiding these common keto mistakes, you should be on your way to reaching your weight loss goal. Following the above tips will help you lose 10 pounds in 1 week while following a low-carb ketogenic diet. 1. Bueno, Nassib Bezerra, et al. “Very-Low-Carbohydrate Ketogenic Diet v. Low-Fat Diet for Long-Term Weight Loss: a Meta-Analysis of Randomised Controlled Trials.” The British Journal of Nutrition, U.S. 2. Brehm, Bonnie J, et al. “A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women.” The Journal of Clinical Endocrinology and Metabolism, U.S. 3. Prabhakar, Amlendu, et al. 4. Cox, Pete J, and Kieran Clarke. 5. Phinney, S D, et al. “The Human Metabolic Response to Chronic Ketosis without Caloric Restriction: Preservation of Submaximal Exercise Capability with Reduced Carbohydrate Oxidation.” Metabolism: Clinical and Experimental, U.S. 6. Borer, Katarina T, et al. “Two Bouts of Exercise before Meals, but Not after Meals, Lower Fasting Blood Glucose.” Medicine and Science in Sports and Exercise, U.S. Hi, I'm Tina, a mom, and wife who loves to write about nutrition and dieting. When I'm not writing, I also enjoy baking healthy pastries with my 7-year-old daughter.


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